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iCELLis single-use bioreactor

A single-use bioreactor for adhesive cell culture, ideal for AAV and LV vector production. Scalable from research and development to commercial production!

The iCELLis® single-use bioreactor is an integrated high-density cell culture bioreactor that combines the advantages of single-use technology and fixed-bed bioreactors to simplify processes. Designed with a focus on rapid setup and ease of use, this compact system allows for a cell adhesion area of 4 square meters in a benchtop system, and commercial production systems can achieve a maximum culture area of 500 square meters with just 3.2 square meters of footprint! It enables cell seeding at lower densities (1000 cells/cm² for Vero cells), significantly reducing manual labor and associated costs by simplifying the process. **Features** - Simplification of the process from pre-culture to product - Integrated single-use bioreactor - Rapid process development due to simple structure - Linear scalability from research and development to actual production - High cell density achieves reduced volume and increased productivity compared to traditional tank stirred bioreactors *For more details, please refer to the PDF document or feel free to contact us.*

  • iCELLis シングルユースバイオリアクター2.jpeg
  • iCELLis シングルユースバイオリアクター3.jpeg
  • iCELLis シングルユースバイオリアクター4.jpeg
  • iCELLis シングルユースバイオリアクター5.jpeg
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[Case Study] Amplification Efficiency of Bacteriophages

User-friendly airlift-type single-use bioreactor suitable for bacterial culture.

We would like to introduce a case study by Proteon Pharmaceuticals, a Polish company, which evaluated the amplification efficiency of Salmonella enterica enteritidis bacteriophage using the CellMaker single-use bioreactor system. The optical density of the bacteria was measured every 30 minutes. The dynamics of the optical density (OD) were compared between the culture of the bacteria alone and the culture with the addition of phage. The test results demonstrated successful culture and high-efficiency amplification of Salmonella enterica enteritidis serotype. Furthermore, process optimization was conducted to improve phage yield, and this process is now adopted as part of the production process. [Overview] ■ Equipment used: CellMaker single-use bioreactor system ■ Experiment content: Production of bacteriophage in Salmonella enteritidis culture *For more details, please download the PDF or feel free to contact us.

  • Other physicochemical equipment

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Allegro STR Single-Use Bioreactor

Single-use lower agitation type bioreactor. Suitable for suspension cell culture applications. High stirring capability! Safe at a total height of under 3m even for 2,000L.

The Allegro(TM) STR single-use bioreactor achieves high mixing capabilities and a low overall height of less than 3 meters, even with a capacity of 2,000 L, thanks to its rectangular culture vessel, which surpasses the performance of traditional cylindrical culture vessels. ■ High Mixing Capability The effective baffle effect of the rectangular culture vessel and the elephant ear-shaped mixing blades allow for the desired oxygen transfer rate to be achieved at lower stirring speeds than before. This results in high kLa and P/V values, reducing shear stress on cells during cultivation at lower stirring speeds. ■ Geometric Similarity Across All Scales, Including Mixing Blades Maintains a similar shape across all scales of 50, 200 L, 500 L, 1,000 L, and 2,000 L. ■ Scalable with Constant P/V Due to geometric similarity and the ability to achieve high P/V values, scaling up with constant P/V is possible. ■ Overall Height Below 3 M Even at 2,000 L Significantly reduces the need for high-altitude work, ensuring the safety of operators. ■ Easy Installation of Dedicated Culture Bags After transporting the single-use culture bag into the culture vessel, it can be set up within 30 minutes with minimal operator intervention.

  • Allegro STR シングルユースバイオリアクター2.jpeg
  • Allegro STR シングルユースバイオリアクター3.jpeg
  • Allegro STR シングルユースバイオリアクター4.jpeg
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Ambr250 High Throughput Gen2

Industry-standard high-throughput bioreactor system optimized for process characteristic analysis.

The Ambr 250 High Throughput Generation 2 is a multi-parallel bioreactor system that accelerates process development and characterization analysis schedules to achieve cost reduction. Its fully continuous gas supply system realizes similarity with large-scale bioreactors and optimizes the scale-down model. Through the integration of analysis options such as the capacitance-based BioPAT Viamass, it supports extensive feedback control.

  • Ambr-250HT-mam-001-5G21_10006-b.png
  • Ambr250HT-Perf-TFF-6643-yellow-a-3.png
  • others
  • Culture Equipment
  • Bioreactor

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